Publications
Full list of publications
Authors in bold denote Brien lab members
Preprints
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity.
Doherty AM, Lagan E, Elliott RJR, Wynne K, Monger C, Bracken AP, Shi J, Vakoc CR, Armstrong SA, Oliviero G, Ott C, Carragher NO, Brien GL
2025
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma.
Lagan E, Gannon D, Silva AJ, Bibawi P, Doherty AM, Nimmo D, McCole R, Monger C, Genesi GL, Vanderlinden A, Innes JA, Jones CLE, Yang L, Chen B, van Mierlo G, Jansen PWTC, Pednekar C, Von Kriegsheim A, Wynne K, Sánchez-Rivera FJ, Soto-Feliciano YM, Carcaboso AM, Vermeulen M, Oliviero G, Chen CW, Phillips RE, Bracken AP, Brien GL
A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.
McCole R, Nolan J, Reck DM, Monger C, Rustichelli S, Conway E, Brien GL, Wang C, Deevy O, Neikes HK, Bashore FM, Mooney A, Flavin R, Vandenberghe E, Flanigan SF, Pasini D, Davidovich C, Vermeulen M, James LI, Healy E, Bracken AP.
Featured in Molecular Cell preview article
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
2021
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells.
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP.
2019
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer.
Bracken AP, Brien GL, Verrijzer CP.
Targeting chromatin complexes in fusion protein-driven malignancies.
Brien GL, Stegmaier K, Armstrong SA.
The 3D Genome: EZH2 Comes into the Fold.
Brien GL, Bracken AP.
2018
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma.
Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA.
2017
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.
Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE.
2016
NUP98 Fusion Proteins Interact with the NSL and MLL1 Complexes to Drive Leukemogenesis.
Xu H, Valerio DG, Eisold ME, Sinha A, Koche RP, Hu W, Chen CW, Chu SH, Brien GL, Park CY, Hsieh JJ, Ernst P, Armstrong SA.
Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.
Oliviero G, Brien GL, Watson A, Streubel G, Jerman E, Andrews D, Doyle B, Munawar N, Wynne K, Crean J, Bracken AP, Cagney G.
Molecular and Cellular Proteomics (2016)
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.
Brien GL, Valerio DG, Armstrong SA.
The PCL1-p53 axis promotes cellular quiescence.
Brien GL, Bracken AP.
2015
A chromatin-independent role of Polycomb-like 1 to stabilize p53 and promote cellular quiescence.
Brien GL, Healy E, Jerman E, Conway E, Fadda E, O'Donovan D, Krivtsov AV, Rice AM, Kearney CJ, Flaus A, McDade SS, Martin SJ, McLysaght A, O'Connell DJ, Armstrong SA, Bracken AP.
Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.
Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP.
2012
Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation.
Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP.
2009
Transcriptomics: unravelling the biology of transcription factors and chromatin remodelers during development and differentiation.
Brien GL, Bracken AP.